CHROMOSOME 22 CENTRAL 
SUPPORT FOR ALL CHROMOSOME 22 RELATED DISORDERS 

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C22C is a parent driven group with more than 1000 members in 45+ countries. 

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MESSAGE BOARDS

• Trisomy 22 and Rare C22 Disorders

• Cat Eye Syndrome 

• 22q Deletions

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LEARN ABOUT

• Chromosome 22 Central

• 22q11 Deletion Syndrome (DiGeorge Syndrome, Velocardiofacial Syndrome)

• Microduplication 22q11 Syndrome

• The 11/22 Translocation (Emanuel Syndrome, partial trisomy 11/22)

• 22q13 Deletion Syndrome (Phelan-McDermid Syndrome)

• Cat Eye Syndrome

• Complete or Full Trisomy 22

• Mosaic Trisomy 22

• Chromosome 22 Ring

• Monosomy 22 Mosaicism 

• Unique Chromosome 22 Disorders

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 NEWSLETTERS

• NOVEMBER 2006
• FEBRUARY 2007 
• MAY 2007 
• SEPTEMBER 2007
• DECEMBER 2007 
• MAY 2008

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Chromosome 22 Central Inc. is a registered Canadian Non-Profit Organization 
and Registered Charity BN# 86009 3665 RR0001, and a Registered US Corporation with Non-Profit Status

RING 22

Post to the Ring 22 Message Board

Chromosome 22 Ring is a very rare disorder which is caused by the breakage of chromosome 22 at each of its ends, and then reconnecting to form a ring. The amount of genetic material that is lost when the chromosome breaks will determine how affected the child is. Some may have no apparent symptoms, and some can be significantly affected. The most common findings in this disorder are mental retardation, hypotonia (muscle weakness) and lack of coordination.

Other symptoms that have been found in some patients with Chromosome 22 Ring maybe be a smaller or larger nose than normal, large ears, high arched palate, wide-spaced eyes, drooping eyelids. In rarer cases, some patients present underdeveloped toenails, webbed finger or toes, small eyes, long eyelashes and heart defects. Click here for a more complete list of findings in Ring 22.

There is no known cause of this disorder, it usually arises spontaneously, and the parents of the affected child usually have normal chromosomes

Full text article links (outside of c22c.org):  

Distinctive Phenotype in a Case of Ring Chromosome 22 with Features of 22q13.3 Deletion Syndrome

Ring Chromosome 22 Resulting in Partial monosomy in a Mentally Retarded Boy - Singapore Journal of Medicine

Ring 22 duplication/deletion mosaicism: clinical, cytogenetic, and molecular characterisation.

Molecular Characterization of Ring Chromosome 22 in a patient with severe language delay: a contribution to the refinement of the subtelomeric 22q deletion syndrome. 2002.

List of Ring 22 Reference Articles

• Ring 22 e-mail list available for families (not part of C22C)
• A Yahoo email list for ring 22 families (not part of C22C)

Additional lists in French:

• Anneau 22 (FRENCH)
• Alliance 22 (FRENCH)

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USA members for DONATIONS Please forward a cheque or money order to our US HEAD OFFICE so that you can obtain a tax receipt.

Head Office - for ALL inquiries: Chromosome 22 Central, c/o Stephanie St-Pierre, 237 Kent Avenue, Timmins, Ontario, Canada P4N 3C2 
tel/fax: (705) 268-3099, EMAIL:  steph.stpierre@gmail.com

US Head Office - donations only: Chromosome 22 Central, c/o Murney Rinholm, 7108 Partinwood Drive, Fuquay-Varina, North Carolina, 27526  USA, 
tel (919) 567-8167, EMAIL: bgr@nc.rr.com